The show is set in a small town in Louisiana that gets its first "out" vampire. The focal characters are the vampire, named Bill, and a waitress, named Sookie, who works at the local watering hole. However she is much more than just a waitress. Sookie is being played by Anna Paquin, who is fast becoming a favorite of mine. While most people know her from her Oscar winning performance in the 1993 film The Piano, according to IMDb she proceeded that as the English voice of Sheeta in Hayao Miyazaki's Tenkû no shiro Rapyuta (US title "Castle in the Sky").
True Blood looks like it will be a winner and has already been picked up for season two, scheduled to air in January 2009. If you get HBO I highly recommend giving this show a whirl. After all, with Buffy gone, we need a good vampire show.
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